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CD38/ADPRC1  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10818-H08H-50
10818-H08H-20
10818-H08H-10
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20 µg 
10 µg 
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Expression host: Human Cells  
10818-H32H-50
10818-H32H-20
10818-H32H-10
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20 µg 
10 µg 
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Expression host: Human Cells  
50191-M08H-50
50191-M08H-20
50191-M08H-10
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20 µg 
10 µg 
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Expression host: Human Cells  
80229-R02H-20
80229-R02H-10
20 µg 
10 µg 
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Expression host: Human Cells  
80229-R08H-20
80229-R08H-10
20 µg 
10 µg 
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Expression host: Human Cells  
90050-C02H-50
90050-C02H-20
90050-C02H-10
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20 µg 
10 µg 
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Expression host: Human Cells  
90050-C08H-20
90050-C08H-10
20 µg 
10 µg 
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  • Slide 1
Expression host: Human Cells  
65003-T08H-20
65003-T08H-10
20 µg 
10 µg 
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CD38/ADPRC1 Related Area

CD38/ADPRC1 Related Pathways

    CD38/ADPRC1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD38/ADPRC1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CD38/ADPRC1 Summary & Protein Information

    CD38/ADPRC1 Background

    Catalytic activity: NAD(+) + H(2)O = ADP-D-ribose + nicotinamide. {ECO:0000269|PubMed:16690024}.; NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide. {ECO:0000269|PubMed:16690024}.
    Enzyme regulation: ENZYME REGULATION: ATP inhibits the hydrolyzing activity.
    Subcellular location: Membrane; Single-pass type II membrane protein.
    Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269|PubMed:9074508}.
    Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
    Sequence similarity: Belongs to the ADP-ribosyl cyclase family. {ECO:0000305}.
    General information above from UniProt

    The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.

    CD38/ADPRC1 Alternative Name

    T10,ADPRC1, [homo-sapiens]
    CD38,T10, [human]
    CD38,Cd38-rs1, [mouse]
    ADPRC1,Cd38-rs1, [mus-musculus]

    CD38/ADPRC1 Related Studies

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
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