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CD30/TNFRSF8  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10777-H03H-200
10777-H03H-100
200 µg 
100 µg 
Add to Cart
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Description: Active  
Expression host: Human Cells  
10777-H08H-200
10777-H08H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1

CD30/TNFRSF8 Related Area

CD30/TNFRSF8 Related Pathways

CD30/TNFRSF8 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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CD30/TNFRSF8 Summary & Protein Information

CD30/TNFRSF8 Background

Subunit structure: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. {ECO:0000269|PubMed:10518213, ECO:0000269|PubMed:8627180, ECO:0000269|PubMed:8999898, ECO:0000269|PubMed:9168896, ECO:0000269|PubMed:9511754}.
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm.
Post-translational: Phosphorylated on serine and tyrosine residues.
Sequence similarity: Contains 6 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

CD30/TNFRSF8 Alternative Name

CD30,Ki-1,D1S166E, [homo-sapiens]
CD30,D1S166E,Ki-1,TNFRSF8, [human]
Ki,Cd30,D1S166E,Ki-1,RP23-306F22.1,Tnfrsf8, [mouse]
Ki,Cd30,Ki-1,D1S166E, [mus-musculus]

CD30/TNFRSF8 Related Studies

  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"