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BCAM / CD239  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
10238-H02H-200
10238-H02H-100
200 µg 
100 µg 
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Expression host: Human Cells  
10238-H08H-200
10238-H08H-100
200 µg 
100 µg 
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Expression host: Human Cells  
50960-M02H-50
50960-M02H-20
50 µg 
20 µg 
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Expression host: Human Cells  
50960-M08H-50
50960-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
80222-R08H-50
80222-R08H-100
50 µg 
100 µg 
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BCAM / CD239 Related Area

BCAM / CD239 Related Pathways

    BCAM / CD239 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    BCAM / CD239 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Featured Reagent Products

    BCAM / CD239 Summary & Protein Information

    BCAM / CD239 Background

    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
    Developmental stage: Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.
    Post-translational: Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. {ECO:0000269|PubMed:15975931}.
    Sequence similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

    BCAM / CD239 Alternative Name

    AU,LU,CD239,MSK19, [homo-sapiens]
    AU,BCAM,CD239,LU,MSK19, [human]
    1200005K12Rik,Bcam,B-CAM,Gplu,Lu, [mouse]
    lu,Gplu,B-CAM,1200005K12Rik, [mus-musculus]

    BCAM / CD239 Related Studies

  • Kikkawa Y, et al. (2005) Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues. Connect Tissue Res. 46 (4-5): 193-9.
  • El Nemer W, et al. (2007) Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. Blood. 109 (8): 3544-51.
  • Colin Y, et al. (2008) Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfus Clin Biol. 15 (6): 402-5.
  • El Nemer W, et al. (2008) Role of Lu/BCAM in abnormal adhesion of sickle red blood cells to vascular endothelium. Transfus Clin Biol. 15 (1-2): 29-33.
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