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CD16a/Fc gamma RIIIa  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10389-H08H-50
10389-H08H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
10389-H08H1-50
10389-H08H1-100
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100 µg 
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Description: Active  
Expression host: Human Cells  
10389-H27H-50
10389-H27H-100
50 µg 
100 µg 
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Expression host: Human Cells  
10389-H27H1-50
10389-H27H1-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
10389-H27H1-B-50
10389-H27H1-B-20
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20 µg 
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Description: Active  
Expression host: Human Cells  
10389-H27H-B-50
10389-H27H-B-20
50 µg 
20 µg 
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Expression host: CHO Cells  
10389-H08C1-50
10389-H08C1-100
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100 µg 
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Expression host: CHO Cells  
10389-H08C-50
10389-H08C-100
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100 µg 
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Expression host: Human Cells  
80017-R08H-50
80017-R08H-100
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100 µg 
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CD16a/Fc gamma RIIIa Related Area

CD16a/Fc gamma RIIIa Related Pathways

    CD16a/Fc gamma RIIIa Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CD16a/Fc gamma RIIIa Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    CD16a/Fc gamma RIIIa Summary & Protein Information

    CD16a/Fc gamma RIIIa Background

    Subunit structure: Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 (By similarity). {ECO:0000250}.
    Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Exists also as a soluble receptor.
    Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
    Post-translational: Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. {ECO:0000269|PubMed:21768335, ECO:0000269|PubMed:22023369}.; The soluble form is produced by a proteolytic cleavage.
    Involvement in disease: DISEASE: Immunodeficiency 20 (IMD20) [MIM:615707]: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). Note=The disease is caused by mutations affecting the gene represented in this entry. {ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:8608639, ECO:0000269|PubMed:8609432, ECO:0000269|PubMed:8874200}.
    Sequence similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.

    CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

    CD16a/Fc gamma RIIIa Alternative Name

    CD16a/Fc gamma RIIIa Related Studies

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"