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C8A  Protein, Antibody, ELISA Kit, cDNA Clone

C8A Related Area

C8A Related Pathways

    C8A Related Protein, Antibody, cDNA Gene, and ELISA Kits

    C8A Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    C8A Summary & Protein Information

    C8A Background

    Subunit structure: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. {ECO:0000269|PubMed:17692377, ECO:0000269|PubMed:18440555, ECO:0000269|PubMed:7440581}.
    Subcellular location: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
    Involvement in disease: DISEASE: Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the complement C6/C7/C8/C9 family. {ECO:0000305}.; Contains 1 EGF-like domain. {ECO:0000305}.; Contains 1 LDL-receptor class A domain. {ECO:0000255|PROSITE-ProRule:PRU00124}.; Contains 1 MACPF domain. {ECO:0000255|PROSITE-ProRule:PRU00745}.; Contains 2 TSP type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00210}.
    General information above from UniProt

    C8A Alternative Name

    C8A Related Studies

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