Protein, Antibody, ELISA Kit, cDNA Clone BTLA/CD272 Related Area BTLA/CD272 Related Protein, Antibody, cDNA Gene, and ELISA Kits BTLA/CD272 Related Protein, Antibody, cDNA Gene, and ELISA Kits Featured Reagent Products BTLA/CD272 Background
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).