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BTLA/CD272  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
11895-H02H-50
11895-H02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
51060-M02H-50
51060-M02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
81142-R05H-50
81142-R05H-100
50 µg 
100 µg 
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Description:   
Expression host: Human Cells  
90250-C02H-50
90250-C02H-100
50 µg 
100 µg 
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  • Slide 1

BTLA/CD272 Related Area

BTLA/CD272 Related Pathways

    BTLA/CD272 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    BTLA/CD272 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    BTLA/CD272 Summary & Protein Information

    BTLA/CD272 Background

    Subunit structure: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM. {ECO:0000269|PubMed:12796776, ECO:0000269|PubMed:14652006, ECO:0000269|PubMed:15568026, ECO:0000269|PubMed:16169851}.
    Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    Post-translational: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. {ECO:0000269|PubMed:15568026}.; N-glycosylated. {ECO:0000269|PubMed:12796776}.
    Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

    BTLA/CD272 Alternative Name

    BTLA1,CD272, [homo-sapiens]
    B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,BTLA1,CD272, [human]
    A630002H24,B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein, [mouse]
    A630002H24, [mus-musculus]

    BTLA/CD272 Related Studies

  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"