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ACVR2B/Activin RIIB  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10229-H02H-200
10229-H02H-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
10229-H08H-200
10229-H08H-100
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100 µg 
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Description: Active  
Expression host: Human Cells  
50173-M03H-50
50173-M03H-100
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100 µg 
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Description: Active  
Expression host: Human Cells  
50173-M08H-50
50173-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
90056-C08H-200
90056-C08H-100
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100 µg 
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Expression host: Human Cells  
90056-C02H-200
90056-C02H-100
200 µg 
100 µg 
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Expression host: Human Cells  
90056-CCCH-50
90056-CCCH-100
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100 µg 
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ACVR2B/Activin RIIB Related Area

ACVR2B/Activin RIIB Related Pathways

ACVR2B/Activin RIIB Related Protein, Antibody, cDNA Gene, and ELISA Kits

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ACVR2B/Activin RIIB Summary & Protein Information

ACVR2B/Activin RIIB Background

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Subunit structure: Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. {ECO:0000269|PubMed:12941698, ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:8622651}.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Post-translational: Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity. {ECO:0000269|PubMed:8622651}.
Involvement in disease: DISEASE: Heterotaxy, visceral, 4, autosomal (HTX4) [MIM:613751]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. {ECO:0000269|PubMed:9916847}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

ACVR2B/Activin RIIB Alternative Name

HTX4,ACTRIIB,ActR-IIB, [homo-sapiens]
HTX4,Activin RIIB, [Human]
ActRIIB,Acvr2b,MGC118477, [mouse]
ActRIIB, [mus-musculus]

ACVR2B/Activin RIIB Related Studies

  1. Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
  2. Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
  3. Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  4. Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
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